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. 2021 Apr 30;9:e11275. doi: 10.7717/peerj.11275

Figure 3. PMS2 and LIG4, essential components of MMR and NHEJ are downregulated in multiple cell lines.

Figure 3

Differential gene expression was calculated for each gene as log2 fold change for (A) MMR genes in 1% O2, (B) MMR genes in 0.1% O2, (C) NHEJ genes in 1% O2, and (D) NHEJ in 0.1% O2, with respect to the expression level at 21% O2. Red shaded area denotes fold change values below the +/−0.58log2fold (+/−1.5-fold) threshold of change. Blue area denotes fold change values above the designated threshold. Filled shapes represent data which is statistically significant (p < 0.01), whereas hollow shapes show no statistical significance. Data are represented as the mean of three independent experiments.