Figure 3.

A schematic illustration of the Notch signaling pathway involved in the regulation of response of cancer cells to 5-FU via various non-coding RNAs. Notch signaling cascade is involved in the various processes of normal morphogenesis, such as cell growth, apoptosis, as well as the acquisition of drug resistance. LINC00152 could elevate tumor cell migration and invasion, and confer 5-FU resistance in colorectal cancer via modulating the expression level of NOTCH1 through sponging miR-139-5p and downregulating its function from enhancing CRC development (134). Additionally, miR-34a acts as a tumor suppressor and could directly downregulate the expression level of DLL1 as a ligand of the Notch signaling cascade, and thereby could inhibit tumor growth under 5-FU treatment by promoting chemosensitivity to this agent (51).