Table 6.
Role of lncRNAs in the modulation of response to 5-FU in colorectal cancer (ANT, adjacent normal tissue).
| lncRNA | Human/Animal | Assessed Cell line | Targets/Regulators | Function | Ref |
|---|---|---|---|---|---|
| HOTAIRM1 | athymic mice/human: 56 pairs of CRC and ANTs | HCT116, SW480, NCM460, HCT116/5-FU, SW480/5-FU | miR-17-5p, MRP1, MDR1, BTG3, E-cadherin, N-cadherin | HOTAIRM1 via sponging endogenous miR-17-5p/BTG3 axis could suppress cell progression in 5-FU resistant CRC cells. | (123) |
| HOTAIR | 48 pairs of CRC and ANTs | HT29, SW480, FHC, HT29/5-FU, HCT116, SW620, SW1116, lovo, RKO, colon205 | miR-218, VOPP1, TS, AKT, ERK, E2F-1, NF-kB | HOTAIR via suppressing miR-218 and activating NF-kB/TS signaling could contribute to 5-FU resistance. | (124) |
| uc010vzg.1, ENST00000468960 | Microarray | HCT116, HCT116/5-FU | JAK/STAT, PI3K/AKT, NF-kB | Any change in lncRNA expression could be involved in 5-FU-based CRR in CRC cells. | (125) |
| PCAT6 | 73 pairs of CRC and ANTs | HCT116, HT‐29, SW620, SW480, DLD‐1, RKO, LoVo, 293T, CCD‐112CoN |
miR‐204, HMGA2, PI3K/AKT | Overexpression of PCAT6 by inhibiting miR‐204 thereby promoting HMGA2/PI3K axis could enhance the chemoresistance of CRC cells to 5‐FU. | (126) |
| NEAT1 | 55 pairs of CRC and ANTs | FHC, HT29, HCT8, HCT116, SW480, SW620 | miR-34a, Caspase-3, LC3 II/I, ULK1, Beclin-1, ATG9A, ATG4B, HMGB1 | NEAT1 silencing could attenuate autophagy to elevate 5-FU sensitivity in CRC. | (127) |
| NEAT1 | male BALB/c-nude mice/human; 30 pairs of CRC and ANTs | SW480, HCT116, NCM460 | miR-150-5p, CPSF4, P-gp, GST-π | NEAT1 via the miR-150-5p/CPSF4 axis could regulate 5-Fu sensitivity in CRC. | (128) |
| ENST00000547547 | – | HCT116, LoVo, LoVo/5-FU, HCT116/5-FU | miR-31, Bax, Bcl-2 | ENST00000547547 via competitive binding to miR-31 could reduce the 5-FU resistance of CRC cells. | (129) |
| UCA1 | 119 pairs of CRC and ANTs | 293T, HCT8, HCT116, HT29, LoVo, SW480, | miR-204-5p, CREB1, Bcl-2, RAB22A | UCA1 by inhibiting miR-204-5p could increase cell proliferation and 5-FU resistance in CRC. | (130) |
| XIST | 268 pairs of CRC and ANTs | HT29, HCT116, FHC, HT29/5-FU, HCT116/5-FU | TS | XIST via promoting thymidylate synthase expression could inhibit 5-FU-induced CRC cell cytotoxicity. | (131) |
| TUG1 | 124 pairs of CRC and ANTs | HCT8Fu, HCT8, HCT116, SW1116 | miR-197-3p, TYMS | TUG1 by acting as a ceRNA of miR-197-3p could mediate 5-FU resistance in CRC. | (132) |
| HAND2-AS1 | nude mice/human; 27 pairs of CRC and ANTs | NCM460, HCT116, SW480, HCT116/5-FU, SW480/5-FU | miR-20a, PDCD4, Bax, Bcl-2, MMP2, MMP9 | HAND2-AS1 by modulating miR-20a/PDCD4 axis could inhibit 5-FU resistance in CRC. | (133) |
| LINC00152 | nude BALB/c mice/human; 108 pairs of CRC and ANTs | HCT8, HT29, LoVo, HCT116, SW480, SW620, 293T | miR-139-5p, NOTCH1 | LINC00152 by inhibiting miR-139-5p could promote cell proliferation and confer 5-FU resistance in CRC. | (134) |
| H19 | 110 pairs of CRC and ANTs | HCT8, HCT8Fu, SW1116, 293T, HCT116, Lovo, HT29, SW480, SW620, CCD-18Co |
Caspase-3, PARP, p62, LC3I/II, SIRT1 | H19 by promoting SIRT1-mediated autophagy could confer 5-FU resistance in CRC. | (135) |
| CCAT1 | BALB/c mice/human; 67 pairs of CC and ANTs | HCT 116, SW1417, HT-29, KM12, NCM460 | γ-H2AX, p53, c-Myc | Downregulation of CCAT1 could enhance 5-FU sensitivity in CC cells. | (136) |
| H19, UCA1 | – | HCT116, DLD1, SW480, HCT116/5-FU, DLD-1/5-FU, SW480/5-FU, HCT116/p, DLD-1/p, SW480/p | Rb, p27kip1 | Overexpression of UCA1 and H19 could be involved in the impaired cell cycle in cells susceptible to 5-FU. | (137) |