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. 2021 Apr 28;6(2):e00108-21. doi: 10.1128/mSphere.00108-21

TABLE 2.

Ceftazidime susceptibility (MIC and IC50) measurements of OXA-48 and variants expressed from the low copy number vector pUN in E. coli MG1655 ΔmalF (MP14-23)a

Measurement Data for:
MP14-23 MP14-24
wild-type OXA-48		 MP14-29
L67F		 MP14-26
P68S		 MP14-27
F72L		 MP14-30
F156C		 MP14-31
F156V		 MP14-25
L158P		 MP14-28
G160C		 MP14-32
F72L/G131S		 MP14-33
N146S/L158P
MIC (mg/liter) 0.5 0.5 0.5 1 1 1 2 1 0.5 0.5 1
IC50 (mg/liter) 0.045 0.053 0.074 0.160 0.167 0.161 0.191 0.176 0.114 0.078 0.220
CI95% 0.033–0.061 0.039–0.070 0.057–0.096 0.128–0.201 0.136–0.205 0.135–0.192 0.153–0.239 0.142–0.219 0.087–0.148 0.062–0.097 0.164–0.295
a

Susceptibility was determined based on a minimum of 2 biological replicates. The 95% confidence intervals (CI95%) were calculated for the IC50 values.