Table 5.
CYP genes in zebrafish and human
| Zebrafish | Human | Zebrafish | Human | Zebrafish | Human |
|---|---|---|---|---|---|
| CYP1A1 | CYP1A1/1A2 | CYP3A65 | CYP3A-se1,-se2a | CYP19A1, 2 | CYP19A1 |
| CYP1B1 | CYP1B1 | CYP3C1-4 | CYP3A3, 4, 7 | CYP20A1 | CYP20A1 |
| CYP1C1, 2 | - | CYP4F43 | CYP4F | CYP21A1 | CYP21A2 |
| CYP1D1 | CYP1D1P | CYP4V7, 8 | CYP4V2 | CYP24A1 | CYP24A1 |
| CYP2Ks | CYP2W1 | CYP4T8 | - | CYP26A1 | CYP26A1/C1 |
| CYP2N13 | CYP2J2 | CYP5A1 | CYP5A1 | CYP26B1 | CYP26B1 |
| CYP2Ps | CYP2J2 | CYP7A1 | CYP7A1 | CYP26C1 | - |
| CYP2R1 | CYP2R1 | CYP7B1 | CYP7B1 | CYP27A3-7 | CYP27A1 |
| CYP2U1 | CYP2U1 | CYP7C1 | - | CYP27B1 | - |
| CYP2V1 | CYP2J2 | CYP8A1 | CYP8A1 | CYP27C1 | - |
| CYP2X1-10 | - | CYP8B1-3 | CYP8B1 | CYP39A1 | CYP39A1 |
| CYP2Y3, 4 | CYP2A/B/F/S | CYP11A1, 2 | CYP11A1 | CYP46A1 | CYP46A1 |
| CYP2AA1-12 | - | CYP11C1 | - | CYP46A2, 4, 5 | - |
| CYP2AD2, 3, 6 | CYP2J2 | CYP17A1, 2 | CYP17A1 | CYP51A1 | CYP51A1 |
| CYP2AE1, 2 | - |
a-In human, CYP3A-se1 and CYP3A-se2 are single exon pseudogene and share synteny with zebrafish CYP3A65 gene. Zebrafish CYP3A65 is induced by PXR agonist.