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. 2021 Apr 19;12:641378. doi: 10.3389/fimmu.2021.641378

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Copyright © 2021 Luo, Xue, Cai, Lin, Tang, Song, Liu, Mao, Yuan, Zhou, Liu, Wu, Sun and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination of lymphocyte non-specific function and T-SPOT for differentiating ATB from LTBI. (A) Scatter plots showing the results of ESAT-6 spot number, CFP-10 spot number, and PHA spot number in ATB patients (n=49) and LTBI individuals (n=64). Bars indicated the medians and interquartile ranges. **P < 0.01; ***P < 0.001; ns, no significance (Mann-Whitney U test). (B) Scatter plots showing the ratio of MTB-specific antigen spot number/lymphocyte non-specific function in ATB patients (n=49) and LTBI individuals (n=64). Bars indicated the medians and interquartile ranges. *P < 0.05; ***P < 0.001; ns, no significance (Mann-Whitney U test). (C) ROC analysis showing the performance of ESAT-6 spot number and CFP-10 spot number in discriminating ATB patients from LTBI individuals. (D) ROC analysis showing the performance of MTB-specific antigen spot number/lymphocyte non-specific function in discriminating ATB patients from LTBI individuals. (E) Heatmap showing the cluster analysis of lymphocyte non-specific function and T-SPOT results in ATB patients (n=49) and LTBI individuals (n=64). Each rectangle indicates a result of a subject. (F) Venn diagrams showing the overlap of CD4⁺ T cell non-specific function, CD8⁺ T cell non-specific function, NK cell non-specific function, and CFP-10 spot number in ATB patients (n=49) and LTBI individuals (n=64). (G) Scatter plots showing the predictive value of diagnostic model in ATB patients (n=49) and LTBI individuals (n=64). Bars indicated the medians and interquartile ranges. ***P<0.001 (Mann-Whitney U test). Blue dotted line indicates the cutoff value in distinguishing these two groups. (H) ROC analysis showing the performance of diagnostic model based on the combination of CD4+ T cell non-specific function, NK cell non-specific function, and CFP-10 spot number in discriminating ATB patients from LTBI individuals. ESAT-6, early secreted antigenic target 6; CFP-10, culture filtrate protein 10; PHA, phytohemagglutinin; MTB, Mycobacterium tuberculosis; ATB, active tuberculosis; LTBI, latent tuberculosis infection; ROC, receiver operating characteristic; AUC, area under the curve; CI, confidence interval.