Table 3.
The performance of various indicators for distinguishing between ATB and LTBI.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| CFP-10 spot number | 34 | 0.649 (0.540-0.758) | 36.73% (24.66%-50.73%) | 90.63% (81.02%-95.63%) | 75.00% (55.10%-88.00%) | 65.17% (54.83%-74.25%) | 3.92 (1.68-9.13) | 0.70 (0.56-0.88) | 67.26% |
| CD4+ T cell non-specific function (%) | 17.3 | 0.845 (0.767-0.925) | 61.22% (47.25%-73.57%) | 90.63% (81.02%-95.63%) | 83.33% (68.11%-92.13%) | 75.32% (64.65%-83.60%) | 6.53 (2.95-14.44) | 0.43 (0.30-0.61) | 77.88% |
| CD8+ T cell non-specific function (%) | 41.6 | 0.770 (0.683-0.857) | 46.94% (33.70%-60.62%) | 90.63% (81.02%-95.63%) | 79.31% (61.61%-90.16%) | 69.05% (58.51%-77.92%) | 5.01 (2.21-11.34) | 0.59 (0.44-0.77) | 71.68% |
| NK cell non-specific function (%) | 61.7 | 0.691 (0.593-0.789) | 28.57% (17.85%-42.41%) | 90.63% (81.02%-95.63%) | 70.00% (48.10%-85.45%) | 62.37% (52.21%-71.54%) | 3.05 (1.26-7.36) | 0.79 (0.65-0.96) | 63.72% |
| Diagnostic model | 0.57 | 0.939 (0.898-0.981) | 83.67% (70.96%-91.49%) | 90.63% (81.02%-95.63%) | 87.23% (74.83%-94.02%) | 87.88% (77.86%-93.73%) | 8.93 (4.13-19.31) | 0.18 (0.10-0.34) | 87.61% |
ATB, active tuberculosis; LTBI, latent tuberculosis infection; CFP-10, culture filtrate protein 10; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.