Table 4.
The value of ESAT-6/PHA ratio, CFP-10/PHA ratio and TBAg/PHA ratio for discriminating ATB from LTBI.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| ESAT-6/PHA ratio | 0.13 | 0.691 (0.583-0.799) | 40.82% (28.21%-54.75%) | 92.19% (82.98%-96.62%) | 80.00% (60.87%-91.14%) | 67.05% (56.69%-75.97%) | 5.22 (2.11-12.94) | 0.64 (0.50-0.82) | 69.91% |
| CFP-10/PHA ratio | 0.115 | 0.772 (0.676-0.869) | 53.06% (39.38%-66.30%) | 93.75% (85.00%-97.54%) | 86.67% (70.32%-94.69%) | 72.29% (61.84%-80.77%) | 8.49 (3.17-22.73) | 0.50 (0.37-0.68) | 76.11% |
| TBAg/PHA ratio | 0.16 | 0.749 (0.645-0.852) | 53.06% (39.38%-66.30%) | 90.63% (81.02%-95.63%) | 81.25% (64.69%-91.11%) | 71.60% (60.98%-80.27%) | 5.66 (2.53-12.67) | 0.52 (0.38-0.70) | 74.34% |
ESAT-6, early secreted antigenic target 6; CFP-10, culture filtrate protein 10; ATB, active tuberculosis; LTBI, latent tuberculosis infection; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.