Table 5.
The performance of various methods for differentiating ATB from LTBI in participants with positive T-SPOT results.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| ESAT-6/PHA ratio | 0.13 | 0.815 (0.727-0.903) | 48.72% (33.86%-63.80%) | 92.19% (82.98%-96.62%) | 79.17% (59.53%-90.76%) | 74.68% (64.11%-82.97%) | 6.24 (2.53-15.35) | 0.56 (0.41-0.76) | 75.73% |
| CFP-10/PHA ratio | 0.115 | 0.899 (0.837-0.961) | 66.67% (50.98%-79.37%) | 93.75% (85.00%-97.54%) | 86.67% (70.32%-94.69%) | 82.19% (71.88%-89.29%) | 10.67 (4.03-28.26) | 0.36 (0.23-0.56) | 83.50% |
| TBAg/PHA ratio | 0.16 | 0.889 (0.827-0.952) | 64.10% (48.42%-77.26%) | 90.63% (81.02%-95.63%) | 80.65% (63.72%-90.81%) | 80.56% (69.97%-88.05%) | 6.84 (3.08-15.17) | 0.40 (0.26-0.61) | 80.58% |
| Diagnostic model | 0.57 | 0.936 (0.890-0.981) | 82.05% (67.33%-91.02%) | 90.63% (81.02%-95.63%) | 84.21% (69.58%-92.56%) | 89.23% (79.40%-94.69%) | 8.75 (4.03-19.01) | 0.20 (0.10-0.39) | 87.38% |
ATB, active tuberculosis; LTBI, latent tuberculosis infection; ESAT-6, early secreted antigenic target 6; CFP-10, culture filtrate protein 10; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.