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. 2021 Apr 27;12(2):e00085-21. doi: 10.1128/mBio.00085-21

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Copyright © 2021 Liu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — Characterization of cytotoxic and cytokine profiles of T, NK, and NKT-like cells in the PBMCs of individuals recovering from COVID-19. (A) The fold changes of the percentages (median) of granzyme B-, perforin-, IFN-γ-, IL-6-, and GM-CSF-producing NKT-like cells in the blood of CI compared to those of UI are depicted by radar plots. (B) The percentages and MFI (geometric mean) of granzyme B expression of NKT-like cells in the blood of UI (n = 16) and CI (n = 25) were analyzed by flow cytometry. (C) The fold changes of the percentages (median) of granzyme B-, perforin-, IFN-γ-, IL-6-, and GM-CSF-producing CD8 T cells in the blood of CI compared to those of UI are depicted by radar plots. (D) The percentages and MFI (geometric mean) of granzyme B expression of CD8 T cells in the blood of UI (n = 21) and CI (n = 30) were analyzed by flow cytometry. (E) The fold changes of the percentages (median) of granzyme B-, perforin-, IFN-γ-, IL-6-, and GM-CSF-producing CD4 T cells in the blood of CI compared to those of UI are depicted by radar plots. (F) The percentages and MFI (geometric mean) of granzyme B expression of CD4 T cells in the blood of UI (n = 21) and CI (n = 30) were analyzed by flow cytometry. CI, COVID-19-convalescent individuals; UI, SARS-CoV-2-unexposed individuals. Statistically significant differences are indicated by asterisks (*, <0.05; **, <0.01; nonparametric Mann-Whitney test).