FIG 1.

Longitudinal dynamics of CD4⁺ counts, CD4/CD8 ratios, and virological biomarkers during the first 96 weeks of ART. Participants are color-coded. Open circles depict undetectable values, censored to the detection limits. For the US RNA/total DNA ratios, open circles correspond to the samples where US RNA was undetectable and censored to the detection limits; because total DNA in these samples was detectable, these circles depict the upper limits of the US RNA/total DNA ratios. For the US/MS RNA ratios, open crossed circles correspond to the samples where MS RNA was undetectable and censored to the detection limits; because US RNA in these samples was detectable, these circles depict the lower limits of the US/MS RNA ratios. Two samples where both US and MS RNA were undetectable were excluded from the US/MS ratio calculations. For plasma viral load (VL), limits of detection of the commercial assays are shown with dashed lines. Repeated-measures mixed-effects P values (representing the significance values of the change of the parameter between the time points) as well as P values of pairwise comparisons between the biomarker values at different time points (adjusted to account for multiple comparisons) are depicted to the right of the corresponding graphs. Significant effects are shown in red. BL, baseline.