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. 2021 Mar 2;12(2):e00143-21. doi: 10.1128/mBio.00143-21

FIG 9.

FIG 9

Entry model of VSVΔG-BHLD and HSV-1. (A) Entry of VSVΔG-BHLD and HSV-1 into C10 and CHO-HVEM cells occurs by endocytosis and requires dynamin and cholesterol. VSVΔG-BHLD entry into C10 and CHO-HVEM cells additionally requires NHE and Rac1 activity, whereas HSV-1 does not. VSVΔG-BHLD entry into C10 cells, but not CHO-HVEM cells, also requires Rab5 and endosomal acidification. HSV-1 does not require either Rab5 or endosomal acidification for entry into either cell type. (B) Table summarizing the cellular molecules important for HSV-1 and VSVΔG-BHLD entry into C10 and CHO-HVEM cells. Green check marks indicate that the virus requires that cellular component for entry. Red “X” marks indicate that the virus does not require that cellular component for entry.