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. 2021 Mar 30;12(2):e00279-21. doi: 10.1128/mBio.00279-21

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Copyright © 2021 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — Transcriptional changes of naive human MDMs (monocyte-derived macrophages) incubated with live-M-EVs (EVs from live C. neoformans-infected activated human peripheral MDMs). (A) Differentially expressed genes (DEGs) in EV-treated and untreated groups. Red, upregulated; blue, downregulated (n = 3 for each group). (B and C) GO analysis of upregulated (B) and downregulated (C) DEGs. (D and E) KEGG analysis of upregulated (D) and downregulated (E) DEGs. EGFR, epidermal growth factor receptor. (F) Shared DEGs between MDMs and BMDMs identified by Venn analysis. (G) Fold changes of shared DEGs between MDMs and BMDMs. Red squares indicate immune-related pathways. Red asterisks indicate shared GO and KEGG pathways.