FIG 3.

Colonic adenoma burden in the murine Apc^Min/+ model in response to daily Fn7-1 instillation and aspirin supplementation. Conventional specific-pathogen-free Apc^Min/+ mice were orally inoculated with Fn7-1 or a sham control (sTSB) daily and simultaneously maintained on either a control chow or a chow supplemented with 200 ppm aspirin, with both treatments beginning at 6 weeks of age and continuing until 14 weeks. Mice were then sacrificed, and the colons were prepared for histological analysis for enumeration of colon adenomas. Data points represent adenoma counts from individual mice, bars indicate the mean ± SEM, and statistical analysis was performed by Kruskal-Wallis test with post hoc Dunn’s test for multiple comparisons. ****, P < 0.0001.