FIG 3.

Global selection against proviruses oriented with the gene and selection in two genes for with-the-gene proviruses. For each of the integration site libraries, unique integration sites for all genes (A) and for proviruses integrated into BACH2 and STAT5B (B) were plotted as the percentages of integrations against the gene (orange) and with the gene (green). Significance was assessed via Fisher’s exact test between the ex vivo infected PBMC library and the pre-ART and on-ART integration site libraries from children. P values for pre-ART comparisons were post hoc adjusted. The on-ART comparisons were not adjusted because of the differences in the number of independent statistical tests against each library.