FIG 4.

Distribution of integration sites in BACH2 and STAT5B. The maps show the integration sites of the proviruses in ex vivo infected PBMCs (A, D) (Coffin et al., submitted), infants sampled pre-ART (B, E), and children sampled on ART (C, F). Each graph shows the entire gene, divided into 250 bins. For BACH2 (A to C), each bin corresponds to ca. 1,500 nucleotides (nt), and for STAT5B (D to F), ca. 300 nt. Exons (labeled on the x axis, with orientation of transcription shown) are shown as gray bars whose height indicates the level of expression in transcripts per million (TPM), as shown on the scale on the right. Note that the resolution of the text sometimes leads to loss of labels of closely spaced exons. The numbers of integration sites in each bin are indicated by the stacked bars, according to the scale on the left, with red indicating the same transcriptional orientation as the chromosome numbering and blue indicating the opposite orientation. In these two genes, blue indicates the number of proviruses in each bin integrated in the same orientation as the gene.