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. 2021 Apr 8;12(2):e00568-21. doi: 10.1128/mBio.00568-21

TABLE 1.

Number of integration sites and infected cell clones detected in children prior to and on ART

Donor ID Age at ART initiation (mo) No. of integration sites obtained pre-ARTa No. of integration sites detected with >2 breakpoints pre-ART (no. with >1 breakpoint) Oligoclonality indexb (pre-ART) Yrs suppressed on-ART HIV DNA cps/106 PBMC on-ARTc No. of integration sites obtained on-ARTa No. of integration sites detected with >1 breakpoint on-ART Oligoclonality indexb (on ART) No. of integration site matches between pre-ART and on-ARTd
ZA002 17.4 1064 27 (50) 0.085 6.87 33 113 9 0.079 7
ZA003 1.8 1386 7 (30) 0.04 8.06 2 148 16 0.161 0
ZA004e 2.7 655 5 (13) 0.024 7.92/8.76 24/— 255 25 0.223 3
ZA005 6.0 583 2 (14) 0.027 8.04 9 77 4 0.166 1
ZA006 9.0 486 1 (6) 0.012 7.45 47 137 20 0.313 1
ZA007 9.9 197 4 (5) 0.07 8.24 21 85 8 0.403 2
ZA008 2.2 1293 1 (8) 0.006 6.77 42 225 11 0.065 1
ZA009 2.0 809 0 (16) 0.021 9.13 186 125 5 0.055 0
ZA010 1.8 514 1 (12) 0.027 8.35 5 115 3 0.173 0
ZA011 9.3 432 5 (9) 0.037 7.35 182 149 8 0.092 3
ZA012 5.1 1243 3 (12) 0.01 8.41 12 432 32 0.126 2
Median 5.1 655 3 (12) 0.027 8.04 24 137 9 0.161 1
a

Value obtained by counting an integration from both the 5′ and 3′ LTRs as a single integration. Site.

b

As described in Gillet et al. (42) and Bangham (39). This value ranges in the interval [0, 1] are dependent on the relative size and contribution of integration site clones to the data set, where 0 signifies a completely uniform distribution, and 1 signifies a single integration site.

c

Integrase cell-associated DNA (iCAD) protocol (49). —, data not determined.

d

Matches between pre-ART and on ART are counted as clones in columns 4 and 9.

e

Participant ZA004 had on-ART samples from two separate time points, the first when the individual was suppressed for 7.92 years on ART and the second at 8.76 years.