FIG 4.

Clustering of SNVs detected in patient CFR11 based on their temporal changes in allele frequencies. (A) A t-SNE plot depicting the clustering pattern of 3,079 SNVs called in patient CFR11. Most SNVs occur at low allele frequencies (gray). The remaining SNVs form seven distinctly visible genotypes that are labeled and colored accordingly. (B) Changes in the allele frequencies (p) of SNVs belonging to each distinct genotype over time. The colored line indicates mean allele frequency of the genotype. Dark gray ribbons indicate the 95% confidence intervals.