FIG 5.

Assessment of temporal variation in the coverage of specific regions in the genome of P. aeruginosa in patient CFR11. The circos diagram provides an overview of the genome coverage profiles with chromosomal coordinates in kb. The dark gray outer circle depicts regions of the reference genome that have a coverage of at least 5% from the average coverage at at least one time point. The second outermost circle depicts detected phage regions in green. The remaining circles depict normalized coverage profiles for each of the 10 time points sampled for patient CFR11 (innermost, day 0; outermost, day 496). Orange regions indicate lower than average coverage, and purple-blue regions indicate higher than average coverage. Insets highlight three regions that display variant-specific coverage profiles. Each variant is depicted in a distinct color, and the average coverage of the selected region is depicted in gray.