Table 1.

BIPSS results in pediatric population with Cushing disease.

Patient	Pre-oCRH C/P ratio	Post-oCRH stimulation C/P ratio	Tumor location			Treatment outcome	Histopathological confirmation a
			MRI	BIPSS basal/CRH stimulation	Surgery
1	21.5	63.2	normal	R	R	no relapse	microadenoma
2	9.3	23.3	normal	L	C	no relapse	microadenoma
3	0.8	1.1	heterogenous	lateralization (-)	C	no relapse	microadenoma
4	1.5	1.4	normal	lateralization (-)	L	no relapse	microadenoma
5	3.7	19.5	3mm (L)	L	L	no relapse	microadenoma
6	14.9	27.0	heterogenous	R	R	no relapse	microadenoma
7	8.3	22.4	4mm (R)	R	R	2 x surgery RTX bilateral adrenalectomy	1.microadenoma 2.microadenoma
8	1.3	5.6	normal	R	C	2 x surgery	1.microadenoma 2.microadenoma
9	94.5	750.2	normal	R	L	no relapse	corticotropin cell hyperplasia, IHC ACTH (+)
10	43.4	115	heterogenous	R	R	no relapse	pituitary
11	15.8	20.3	heterogenous	R	R	no relapse	microadenoma, IHC ACTH (-)
12	30.7	303.4	normal	L	L	2 x surgery	1.microadenoma, IHC ACTH (+) 2.microadenoma

R, right; L, left; IHC, immunohistochemistry.

^aIHC staining for ACTH was performed since 2016.