Table 2.
Baseline characteristics and biochemical evaluation of 12 pediatric patients with Cushing’s disease.
| No. | Sex | Age at symptoms onset | Age at the time of diagnosis | Duration of disease a (years) | Midnight cortisol (μg/dl) | ACTH (pg/ml)N 10-60 | 24h UFC (μg) | Increase after CRH stimulation | Morning serum cortisol (μg/dl) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACTH (%) | Cortisol (%) | 0’ | LDDST (48h) | HDDST (48h) | ||||||||
| 1 | M | 15.7 | 16.7 | 5 | 13.3 | 66 | 480.8 (<100) | 43.8 | 47 | N.A. | N.A. | N.A. |
| 2 | F | 9.4 | 10.6 | 1.2 | 12.9 | 51 | 849.8 (4-34) | 437.2 | 107 | 26.8 | 4.8 | 13.1 |
| 3 | M | 7 | 15.2 | 8.2 | 23 | 128 | 322.3 (13-120) | 226 | 96 | 21 | 2.2 | 1.7 |
| 4 | F | 10 | 12 | 2.0 | 17.3 | 44.3 | 605 (8.6-52.4) | 259.2 | 139 | 20.3 | 11.4 | 2.2 |
| 5 | F | 8 | 14.3 | 6.3 | 12.6 | 38 | 220.7 (8.6-52.4) | 29.5 | 50 | 20 | 5.3 | 2.6 |
| 6 | M | 10 | 17 | 7.0 | 13 | 43 | 379.6 (13-120) | 0 b | 0 b | 18 | 1.6 | 1 |
| 7 | M | 9 | 11.6 | 2.6 | 49.1 | 45 | 626 (8-65) | 35.1 | 12 | 43.9 | 44.3 | 22.8 |
| 8 | F | 6 | 8.5 | 2.5 | 17.8 | 69 | 260.4 (2.1-23) | 41.2 | 50 | 24.2 | 2 | 1.1 |
| 9 | M | 8 | 10.4 | 2.4 | 7.9 | 118 | 201.4 (8-65) | 334.9 | 295 | 11.2 | 0.7 | 0.5 |
| 10 | M | 10 | 11.7 | 1.7 | 11.8 | 80.2 | 839.2 (8-65) | 35 | 20 | 25.9 | 19.7 | 1.9 |
| 11 | F | 6.3 | 7.2 | 0.8 | 10.4 | 30.7 | 944 (2.1-23) | 143.3 | 56 | 30.2 | 23.8 | 20 |
| 12 | F | 7.0 | 11 | 4.0 | 12.9 | 55.2 | 284 (4-34) | 214.1 | 205 | 15.2 | 10.4 | 3.9 |
a
time interval from the onset of initial symptoms to TSS.
b
in one patient, neither ACTH nor cortisol increased during CRH test.