Table 3.
Literature summary of BIPSS outcome in Cushing’s disease in children.
| Study | Study cohort | Mean age; age range (years) | Study duration | Baseline C/P ratio > 2 | Post-CRH/desmopressin stimulation C/P ratio >3 | Compatibility of localization of a microadenoma by BIPSS with surgical location |
|---|---|---|---|---|---|---|
| Lienhardt et al. (8) | 11 | 12.3 ± 3.9; 10.6-18.8 |
1986-2000 | N.A. | 91% (ratio >2) | 91% d |
| Joshi et al. (18) | 25 (19 BIPSS) |
13.4 6.6-17.8 |
1984-2003 | N.A. | 100% | 73.7%, 94% d |
| Batista et al. (19) | 94 | 13 ± 3.2; 5.3 - 18.7 |
1982-2004 | 90% | 97% | 60.3% (baseline), 58%(CRH stimulation) |
| Shah et al. (20) | 48 (14 BIPSS) |
14.9 ± 2.5; 9-19 | 1988-2008 | 89% a | N.A. | N.A. |
| Storr et al. (21) | 41 (33 BIPSS) |
12.3 ± 3.5; 5.7-17.8 | 1960-2001 | 75.9% | 86.2% | 75.8%, 81.8% d |
| Lonser et al. (22) | 140 | N.A.; 5.8-20.8 |
1982-2010 | N.A. | 99.3 b | 81.8% |
| Yordanova et al. (23) | 21 (19 BIPSS) |
12.1; 5.7-17.8 |
1986-2010 | N.A. | N.A. b | 74% |
| Güemes et al. (24) | 30 | 8.9; 0.2–15.5 |
1983-2013 | 100% | 100% | N.A. |
| Chen et al. (25) | 16 (17 BIPSS) |
15.5 ± 2.9; 9.8-18.7 |
2006-2017 | 64.7% | 83.3% c | 50% (baseline), 42.9% c |
| Cavalcante et al. (26) | 19 | 14; 9-19 |
1993-2017 | 84.2% | 94.4% c | 60% c |
| Authors’ series | 31 (12 BIPSS) |
11.6; 7.2-17 |
2003-2020 | 75% | 83.3% | 58.3%, 66.7% d |
a
baseline ratio criteria ≥ 2.
b
peak ratio criteria ≥3.
c
desmopressin stimulation.
d
total prediction rate (lateralization and no lateralization in case of central adenoma localization).