Table 4.
Dynamic bone histomorphometry at the femoral endocortical (Ec) and periosteal (Ps) mid-diaphysis and at the proximal tibial metaphysis (trabecular only).
| Baseline | Ctrl | PTH | ABL | |
|---|---|---|---|---|
| Endocortical | ||||
| Ec.Tetra.S/BS (%) | 87.1 ± 5.97 | 66.0 ± 11.2 | 66.4 ± 8.18 | 71.5 ± 10.2 |
| Ec.MS/BS (%) | (–) | 40.7 ± 5.51 | 45.1 ± 8.14 | 42.2 ± 15.4 |
| Ec.MAR (μm/d) | (–) | 0.42 ± 0.43 | 0.76 ± 0.58 | 0.67 ± 0.54 |
| Ec.BFR/BS (μm3/μm2/d) | (–) | 0.17 ± 0.19 | 0.33 ± 0.24 | 0.32 ± 0.27 |
| Periosteal | ||||
| Ps.Tetra.S/BS (%) | 36.1 ± 11.5 | 43.0 ± 14.6 | 50.7 ± 14.9 | 57.4 ± 13.6 |
| Ps.MS/BS (%) | (–) | 27.1 ± 9.0 | 38.9 ± 7.70* | 44.2 ± 15.4* |
| Ps.MAR (μm/d) | (–) | 0.10 ± 0.32 | 0.79 ± 0.69* | 0.66 ± 0.66 |
| Ps.BFR/BS (μm3/μm2/d) | (–) | 0.05 ± 0.15 | 0.32 ± 0.28* | 0.33 ± 0.30* |
| Trabecular | ||||
| Tetra.S/BS (%) | 58.8 ± 8.54 | 14.5 ± 6.72 | 8.36 ± 4.84 | 8.10 ± 5.41 |
| MS/BS (%) | (–) | 46.4 ± 5.10 | 46.8 ± 5.65 | 48.0 ± 6.64 |
| MAR (μm/d) | (–) | 1.85 ± 0.37 | 2.39 ± 0.36* | 2.88 ± 0.25* |
| BFR/BS (μm3/μm2/d) | (–) | 0.86 ± 0.19 | 1.11 ± 0.15* | 1.10 ± 0.18* |
Mice were s.c. injected with tetracycline four days before study start and alizarin four and eight days before sacrifice. Tetra.S/BS, tetracycline-covered bone surfaces; MS/BS, mineralizing surface/bone surface; MAR, mineral apposition rate; BFR/BS, bone formation rate; Data are presented as mean ± SD. *p < 0.05 vs. Ctrl. Graphs illustrating the data as box and whisker plots and scatter plots are available in the Supplementary Material (Figure S1).