(A–D) Echocardiographic assessment of cardiac function 2 weeks post-TAC or sham operation. Ejection fraction % (A), fractional shortening % (B), left-ventricular internal diameter (LVID) (C), and posterior wall thickness (D). (E) heart weight to tibia length. (F to J)
Ankrd1 (F), βMHC (G), BNP (H), GRK5 (I), and GRK2 (J) expression relative to 18s rRNA. N=4 NLC Sham mice, N=5 NLC TAC mice, N=4 TgGRK5nt Sham mice, N=4 TgGRK5nt TAC mice for (A) to (J). (* p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001, two-way ANOVA with Tukey’s post-hoc testing).