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. 2021 Apr 29;2021(4):CD010216. doi: 10.1002/14651858.CD010216.pub5

Comparison 1. Nicotine EC versus NRT.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Smoking cessation 3 1498 Risk Ratio (M‐H, Fixed, 95% CI) 1.69 [1.25, 2.27]
1.2 Adverse events 2 485 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.80, 1.19]
1.2.1 4 weeks 1 29 Risk Ratio (M‐H, Fixed, 95% CI) 0.74 [0.31, 1.73]
1.2.2 6 months 1 456 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.81, 1.22]
1.3 Serious adverse events 2 727 Risk Ratio (M‐H, Fixed, 95% CI) 1.37 [0.77, 2.41]
1.3.1 4 weeks 1 29 Risk Ratio (M‐H, Fixed, 95% CI) Not estimable
1.3.2 1 year 1 698 Risk Ratio (M‐H, Fixed, 95% CI) 1.37 [0.77, 2.41]
1.4 Carbon monoxide (ppm) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.4.1 8 weeks 2 136 Mean Difference (IV, Fixed, 95% CI) ‐0.66 [‐1.94, 0.62]
1.5 Heart rate (bpm) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.5.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.6 Systolic blood pressure 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.6.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.7 Blood oxygen saturation 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.7.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.8 3‐HPMA (pmol/mg creatinine) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.8.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.9 NNAL (pmol/mg creatinine)) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.9.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.10 2‐HPMA (pmol/mg creatinine) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.10.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.11 HMPMA (pmol/mg creatinine) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.11.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.12 PheT (pmol/mg creatinine) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.12.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.13 CEMA (pmol/mg creatinine) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.13.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.14 AAMA (pmol/mg creatinine) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.14.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.15 FEV1 (ml) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.15.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.16 FEV1/FVC (%) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.16.1 8 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected