Comparison 3. Nicotine EC versus non‐nicotine EC.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Smoking cessation	4	1057	Risk Ratio (M‐H, Fixed, 95% CI)	1.70 [1.03, 2.81]
3.2 Adverse events	3	601	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.91, 1.11]
3.2.1 1 week	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	1.50 [0.27, 8.19]
3.2.2 6 months	1	298	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.71, 1.34]
3.2.3 12 weeks	1	255	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.94, 1.08]
3.3 Serious adverse events	4	494	Risk Ratio (M‐H, Fixed, 95% CI)	0.60 [0.15, 2.44]
3.3.1 1 week	1	48	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
3.3.2 4 weeks	1	74	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
3.3.3 24 weeks	1	255	Risk Ratio (M‐H, Fixed, 95% CI)	0.60 [0.15, 2.44]
3.3.4 1 year	1	117	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
3.4 Carbon monoxide (ppm)	2	171	Mean Difference (IV, Fixed, 95% CI)	‐2.44 [‐3.91, ‐0.97]
3.4.1 2 weeks	1	25	Mean Difference (IV, Fixed, 95% CI)	‐0.40 [‐3.00, 2.20]
3.4.2 12 weeks	1	146	Mean Difference (IV, Fixed, 95% CI)	‐3.40 [‐5.18, ‐1.62]
3.5 Heart rate	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.5.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.6 Systolic blood pressure	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.6.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.7 FeNO (ppb)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.7.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.8 FEV1 (l)	1		Std. Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.8.1 12 weeks	1		Std. Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.9 FVC (l)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.9.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.10 FEV1/FVC	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.10.1 12 weeks	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected