Comparison 5. Nicotine EC + NRT versus non‐nicotine EC + NRT.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
5.1 Smoking cessation	2	1039	Risk Ratio (M‐H, Fixed, 95% CI)	1.77 [1.07, 2.94]
5.2 Adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.2.1 12 weeks	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.3 Serious adverse events	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.3.1 6 months	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.4 Carbon monoxide (ppm)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
5.4.1 8 weeks	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
5.5 FeNO (ppb)	1	30	Mean Difference (IV, Fixed, 95% CI)	‐0.36 [‐7.23, 6.51]
5.5.1 6 months	1	30	Mean Difference (IV, Fixed, 95% CI)	‐0.36 [‐7.23, 6.51]
5.6 FEV1 (%)	1	32	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.01, 0.10]
5.6.1 6 months	1	32	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.01, 0.10]
5.7 FVC (%)	1	32	Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.03, 0.09]
5.7.1 6 months	1	32	Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.03, 0.09]