Murray 2020.

Study name	Yorkshire Enhanced Stop Smoking (YESS) study: a protocol for a randomized controlled trial to evaluate the effect of adding a personalized smoking cessation intervention to a lung cancer screening program
Methods	RCT Setting: Yorkshire, UK
Participants	Anticipated recruitment: 1040 people who smoke tobacco cigarettes Participants are aged 55 – 80, registered with a general practitioner (GP) in the Leeds Clinical Commissioning Group area and registered as a current or ex‐smoker in primary care databases Inclusion criteria: Attended an lung health check (LHC) and consent to participate in the Yorkshire Lung Screening Trial (YLST) have smoked within the last month have an exhaled carbon monoxide (CO) reading ≥ 6 ppm have agreed to see an SCP on the mobile unit Exclusion criteria: Any individual who does not have an LDCT scan or is unable to provide informed consent
Interventions	Arm 1: enhanced, personalized smoking cessation (SC) support package, including CT scan images. SC support over 4 weeks comprising behavioral support, pharmacotherapy and/or a commercially‐available e‐cigarette Arm 2: continued standard best practice.
Outcomes	Follow‐up contact will be requested at 4 weeks, 3 months and 12 months, with a 2‐week window to accommodate participant availability The primary objective is to measure 7‐day point prevalent carbon monoxide (CO)‐validated SC after 3 months Secondary outcomes include CO‐validated cessation at 4 weeks and 12 months, self‐reported continuous cessation at 4 weeks, 3 months and 12 months, attempts to quit smoking and changes in psychological variables, including perceived risk of lung cancer, motivation to quit smoking tobacco, confidence and efficacy beliefs (self and response) at all follow‐up points
Starting date	January 2019 and December 2020 with follow‐up data collection ending December 2021
Contact information	Professor Rachael L Murray; rachael.murray@nottingham. ac.uk
Notes