Comparison 1. Coenzyme Q10 versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 All cause mortality	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.2 Myocardial infarction	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.3 Stroke	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.4 Revascularisation procedures	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
1.5 Hospitalisation for heart failure	2	1061	Risk Ratio (M‐H, Random, 95% CI)	0.62 [0.49, 0.78]
1.6 Left ventricular ejection fraction (%)	7	650	Mean Difference (IV, Random, 95% CI)	1.77 [0.09, 3.44]
1.7 Exercise capacity: treadmill exercise test duration (seconds)	3	91	Mean Difference (IV, Random, 95% CI)	48.23 [‐24.75, 121.20]
1.8 Exercise capacity: metabolic equivalent on treadmill exercise test (METs)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
1.9 Brain natriuretic peptide (pg/mL)	2	162	Mean Difference (IV, Random, 95% CI)	‐91.97 [‐103.11, ‐80.83]
1.10 Serum levels of coenzyme Q10 (μg/mL)	6	489	Mean Difference (IV, Random, 95% CI)	1.25 [1.09, 1.42]
1.10.1 Studies with coenzyme Q10 dose >200 mg daily	3	377	Mean Difference (IV, Random, 95% CI)	1.13 [0.96, 1.30]
1.10.2 Studies with maximum coenzyme Q10 dose of 200 mg daily	3	112	Mean Difference (IV, Random, 95% CI)	1.46 [1.19, 1.72]
1.11 Aderse events	2	568	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.45, 1.10]