ChiCTR1800016271.

Study name	The effect of intermittent fasting in patients with overweight
Methods	Randomised controlled trial
Participants	Inclusion criteria 1. aged 25 to 65 years,male and female 2. BMI = 24 kg/m2; 3. light physical activity (i.e. < 3 hours/week of light intensity exercise at 2.5 to 4.0 metabolic equivalents (METs) for 3 months prior to the study), weight stable for 3 months prior to the start of this study (i.e. less than 4 kg weight loss or weight gain in recent three months) 4. participants are required to sign informed consent Exclusion criteria 1. women who are either in pre‐menopause or 2 years post menopause 2. patients with diabetes (FPG = 7.0mmol/L and / or OGTT 2‐hour PG = 11.1mmol/L) 3. attended in another study or take weight‐loss drugs at the same time or 3 months prior to the beginning of the study 4. obvious renal insufficiency (creatinine = 1.5 mg/dL or > 133umol/L) 5. obvious abnormal liver function (ALT more than 2 times of the normal upper limit) 6. ever suffered from history of stroke or myocardial infarction; be done or are preparing to do coronary angioplasty or coronary artery bypass grafting 7. other serious diseases such as malignant tumour 8. be preparing for pregnancy; other situations that researchers believe that is not suitable for the selected object
Interventions	1:Intermittent fasting 2:Continuous Energy restriction
Outcomes	BMI; waist circumference;total cholesterol;
Starting date	2018‐06‐01
Contact information	fan_yibing@163.com
Notes