Table 2.
Meta-analytical TLEs for chemicals with homogeneous multi-study data (true TLEs).a
| Category | Chemical | Species | Datasetb | TLE (95% CIs) |
|---|---|---|---|---|
| Parallel | Acetonitrile | Rats | Pozzani (1959) | 1.38 (0.87, 1.88) |
| AEGL probit of pooled studies | 1.55 (0.54, 2.5) | |||
| Pozzani (1959) | 1.35 (0.90, 1.80) | |||
| Union Carbide Corp. (1965) | ||||
| Monsanto (1986) | ||||
| Ammonia | Rats | Appleman (1982) | 2.01 (1.76, 2.26) | |
| Mice | Kapeghian (1982) | 2.18 (2.01, 2.35) | ||
| Mice + Rats | AEGL citation of ten Berge TLE | 2.0 (1.6, 2.4) | ||
| Probit of pooled studies | −3.33 (−17.64, 10.99) | |||
| Rats | Appleman (1982) | 2.13 (1.98, 2.27) | ||
| Mice | Kapeghian (1982) + Silver and McGath (1948) | |||
| Chlorine trifluoride | Rats | Dost (1974) | 1.15 (1.03, 1.27) | |
| AEGL LC50 regression | 1.3 | |||
| Probit of pooled studies | 1.31 (1.08, 1.53) | |||
| Dost (1974) | 1.03 (0.97, 1.10) | |||
| Horn and Weir (1955) + MacEwen and Vernot (1970) | ||||
| Chloropicrin | Rats | Yoshida (1987) | 2.12 (0.16, 4.08) | |
| AEGL probit of pooled studies | 2.31 (1.06, 3.56) | |||
| Yoshida (1987) | 2.12 (−0.27, 4.52) | |||
| Yoshida (1991) | ||||
| Ethylene oxide | Rats | Nachreiner (1992) | 1.39 (0.99, 1.65) | |
| AEGL LC50 regression | 1.21 | |||
| Probit of pooled studies | 1.24 (0.95, 1.53) | |||
| Nachreiner (1992) | 1.39 (0.99 1.78) | |||
| Jacobson (1956) | ||||
| Hydrogen selenide | Rats | Zwart (1992) | 1.96 (1.24, 2.68) | |
| AEGL probit of pooled studies | 2.51 (1.37, 3.66) | |||
| Zwart (1992) | 1.99 (1.32, 2.67) | |||
| Zwart and Arts (1989) | ||||
| Pooled | Allyl alcohol | Rats | Kirkpatrick (2008) | 0.43 (−5e + 4, 5e + 4) |
| Union Carbide Corp. (1965) | 4.54 (−1e + 6, 1e + 6) | |||
| AEGL probit of pooled studies | 0.95 (0.76, 1.15) | |||
| Dimethylamine | Rats | IRDC (1992) | 1.96 (1.43, 2.50) | |
| AEGL LC50 regression | 2.81 | |||
| Probit of pooled studies | 2.19 (1.85, 2.53) | |||
| Hexafluoroacetone | Rats | Dupont (1965) | 1.00 (0.94, 1.06) | |
| AEGL LC50 regression | 0.93 | |||
| Probit of pooled studies | 0.85 (0.77, 0.93) | |||
| Methanesulfonyl chloride | Rats | Pennwalt Corp. (1987) | 0.66 (0.61, 0.71) | |
| AEGL probit of pooled studies | 0.71 (0.30, 1.11) | |||
| Probit of pooled studies (with 45 min data) | 0.71 (0.67, 0.74) | |||
| Methyl iodide | Rats | EPA (2006) | 1.14 (0.61, 1.67) | |
| AEGL probit of pooled studies | 1.81 (1.52, 2.10) | |||
| Oxamyl | Rats | Dupont (1969) | 1.56 (1.13, 1.99) | |
| AEGL LC50 regression | 1.59 | |||
| Probit of pooled studies | 1.46 (1.18, 1.75) | |||
| Peracetic acid | Rats | Janssen (1989) | 14.44 (−94.0, 122.8) | |
| AEGL LC50 regression | 1.6 | |||
| Probit of pooled studies | 3.60 (2.21, 4.99) | |||
| Sulfuric acid | Mice | Runckle and Hahn (1976) (AEGL used probit of mice only) | 1.27 (0.81, 1.73) | |
| Rats | Runckle and Hahn (1976) | 3.25 (1.56, 4.94) | ||
| Mice + Rats | Pooled probit of studies | 1.94 (1.28, 2.60) | ||
| Common-effect meta-analysis | Carbon tetrachloride | Rats | Adams (1952) | 2.42 (1.99, 2.86) |
| Dow Chemical (1960) | 2.79 (2.30, 3.28) | |||
| Mellon Institute (1947) | 1.61 (−2e + 6, 2e + 6) | |||
| AEGL LC50 regression | 2.53 | |||
| Probit of pooled studies | 2.43 (2.09, 2.77) | |||
| Common-effect meta-analysis (p-value for Q = 0.45) | 2.51 (2.27, 2.76) | |||
| Methyl hydrazine | Dogs | Haun (1970) | 0.97 (0.94, 1.01) | |
| Monkeys | Haun (1970) | 1.03 (0.92, 1.13) | ||
| Dogs + Monkeys | AEGL LC50 regression | 0.99 (dogs) 0.97 (monkeys) | ||
| Probit of pooled studies | 0.99 (0.82, 1.16) | |||
| Common-effect meta-analysis (p-value for Q = 0.33) | 0.98 (0.94, 1.01) | |||
| Nitrogen dioxide | Dogs | Hine (1970) | 5.25 (1.53, 8.89) | |
| Guinea pigs | Hine (1970) | 3.85 (2.05, 5.66) | ||
| Mice | Hine (1970) | 4.41 (3.84, 4.99) | ||
| Rabbits | Hine (1970) | 3.39 (2.10, 4.68) | ||
| Rats | Hine (1970) | 3.81 (3.13, 4.49) | ||
| Dogs + Guinea pigs + Mice + Rabbits + Rats | AEGL citation of ten Berge TLE | 3.5 (2.7, 4.3) | ||
| Probit of pooled studies | 3.98 (3.38, 4.57) | |||
| Common-effect meta-analysis (p-value for Q = 0.39) | 3.99 (3.67, 4.31) | |||
| Nitrogen trifluoride | Rats | Vernot (1973) | 1.02 (0.95, 1.09) | |
| Dost (1970) | 1.27 (−3e + 4, 3e + 4) | |||
| Torkelson (1962) | 1.15 (−6e + 4, 6e + 4) | |||
| AEGL probit of pooled studies | 1.23 (1.03, 1.43) | |||
| Probit of pooled studies (with 5000 ppm data) | 1.24 (1.06, 1.42) | |||
| Common-effect meta-analysis (p-value for Q = 1.00) | 1.02 (0.95, 1.09) | |||
| Tear gas (CS, 2-Chlorobenzylidenemalononitrile) | Rats | McNamara (1969) | −0.58 (−5.22, 4.06) | |
| Ballantyne (1972) | 0.71 (0.63, 0.79) | |||
| Ballantyne (1978) | 1.21 (−9.83, 12.25) | |||
| AEGL probit of pooled studies | 0.70 (0.54, 0.87) | |||
| Fixed effects meta-analysis (p-value for Q = 0.86) | 0.71 (0.63, 0.79) |
a
The chemicals are categorized by the statistically most appropriate method of analysis, identified by the bold rows.
b
Shows dataset labels, not the entire inventory of studies. Refer to supporting information for complete listing of studies. “+” denotes pooling.