4. Meta‐regression of effects of SFA reduction on cardiovascular events.

Regression factor	No. of studies	Constant	Coefficient (95% CI)	P value	Proportion of between study variation explained
Change in SFA as %E	8	0.01	0.05 (‐0.03 to 0.13)	0.16	89%
Change in SFA as % of control	8	0.26	0.01 (‐0.01 to 0.03)	0.14	89%
Baseline SFA as %E	8	0.68	‐0.06 (‐0.15 to 0.04)	0.19	81%
Change in TC, mmol/L	12	0.03	0.69 (0.05 to 1.33)	0.04	99%
Change in PUFA as %E	5	‐0.01	‐0.02 (‐0.08 to 0.03)	0.25	100%
Change in MUFA as %E	5	‐0.26	‐0.03 (‐0.14 to 0.09)	0.50	‐87%
Change in CHO as %E	7	‐0.11	‐0.00 (‐0.05 to 0.05)	0.92	‐273%
Change in total fat intake as %E	9	‐0.17	‐0.01 (‐0.03 to 0.01)	0.28	100%
Gender*	13	‐0.17	‐0.14 (‐0.63 to 0.35)	0.55	‐13%
Study duration	13	‐0.47	0.00 (‐0.01 to 0.02)	0.76	‐24.8%
CVD risk at baseline**	13	‐0.44	0.03 (‐0.48 to 0.55)	0.89	‐39%

^{*Gender was coded as follows: 0 = women, 1 = mixed, 2 = men
**CVD risk at baseline was coded as follows: 1 = Low CVD risk, 2 = Moderate CVD risk, 3 = existing CVD
CHO: carbohydrate
CI: confidence interval
CVD: cardiovascular disease
E: energy
MUFA: monounsaturated fatty acid
PUFA: polyunsaturated fatty fat
SFA: saturated fatty acid
TC: total cholesterol}