Summary of findings 3. Preconception lifestyle advice on alcohol intake compared to routine care or attention control for at‐risk drinking women with infertility.
| Preconception lifestyle advice on alcohol intake compared to routine care or attention control for at‐risk drinking women with infertility | ||||||
| Patient or population: women with infertility and at‐risk drinking Setting: university/hospital Intervention: preconception lifestyle advice on alcohol intake Comparison: routine care | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | №. of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with routine care or attention control | Risk with preconception lifestyle advice on alcohol intake | |||||
| Live birth | 381 per 1000 | 438 per 1000 (202 to 952) | RR 1.15 (0.53 to 2.50) | 37 (1 RCT) | ⊕⊝⊝⊝ VERY LOWa,b | Evidence about the effect on live birth of preconception lifestyle advice on alcohol intake is very uncertain |
| Adverse events | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported on this outcome |
| Miscarriage | 95 per 1000 | 125 per 1000 (20 to 794) | RR 1.31 (0.21 to 8.34) | 37 (1 RCT) | ⊕⊝⊝⊝ VERY LOWa,b | Evidence about the effect on miscarriage of preconception lifestyle advice on alcohol intake is very uncertain |
| Reported behavioural changes | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported on this outcome in a way defined by this review |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio. | ||||||
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GRADE Working Group grades of evidence. High quality: further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: we are very uncertain about the estimate. | ||||||
aDowngraded by two levels for very serious risk of bias: high risk for performance bias, attrition bias, and reporting bias.
bDowngraded by two levels for very serious imprecision: one study, few patients (n = 37) and few events; 95% CI includes important benefit and harm.