3. Exacerbations: studies included with time to first exacerbation data.

Study	Treatments compared		Log hazard ratio	Standard error
Albert 2011	Pbo	AZM 250 mg once daily	‐0.31	0.07
He 2010	Pbo	ERY125 mg 3 times daily	‐0.59	0.29
Seemungal 2008	Pbo	ERY 250 mg twice daily	‐0.45	0.14
Simpson 2014	Pbo	AZM 250 mg once daily	‐0.99	0.62
Uzun 2014	Pbo	AZM 500 mg once daily 3 times per week	‐0.54	0.16
Blasi 2010	Pbo	AZM 500 mg once daily 3 times per week	‐1.69	0.60

Abbreviations

AZM: azithromycin; ERY: erythromycin; Pbo: placebo.