10. Change from baseline in SGRQ: included studies.

Study	Endpoint (weeks)	Treatments compared		Mean difference vs Placebo			SE of Mean difference
Albert 2011	52	Placebo	AZM 250 mg once daily	‐2.2			0.7853
Berkhof 2013	12	Placebo	AZM250 mg once daily 3 times per week	‐7.5			2.5456
He 2010	26	Placebo	ERY 125 mg 3 times daily	‐3			5.6801
Sethi 2010	48	Placebo	MOX 400 mg once daily (5 days every 8 weeks)	‐1.2			0.9231
Simpson 2014	12	Placebo	AZM 250 mg once daily	6.1			5.31927
Uzun 2014	52	Placebo	AZM500 mg once daily 3 times per week	‐0.61			2.622449
Brill 2015*	13	Placebo	a. DOX 100 mg once daily b. AZM 250 mg once daily 3 times per week c. MOX 400 mg once daily (5 days every 4 weeks)	a. 1.02	b. ‐2.29	c. ‐1.88	a. 3.135	b. 3.212	c. 3.426
				a. 0.88	b. ‐2.35	c. ‐2.25	a. 3.132	b. 3.085	c. 3.233

Abbreviations

AZM: azithromycin; DOX: doxycycline; ERY: erythromycin; MOX: moxifloxacin; SE: standard error; SGRQ: St George's Respiratory Questionnaire.

*Data in bold used in sensitivity analysis.