13. Serious adverse events: number of trials, participants, and relative effects for all class comparisons.

Treatment class comparison	Number of trials	N	Fixed effect‐fixed class effect model		Random effects‐fixed class effect (uniform prior)		Random effects‐fixed class effect (empirical prior)
			OR	95% CrI	OR	95% CrI	OR	95% CrI
Macrolide vs placebo	8	1930	0.76	0.62 to 0.93	0.72	0.38 to 1.14	0.73	0.45 to 1.07
Quinolone vs placebo	1	1149	1.00	0.72 to 1.34	1.21	0.29 to 3.24	1.08	0.42 to 2.27
Macrolide + tetracycline vs placebo	1	195	0.97	0.52 to 1.66	1.12	0.27 to 2.84	1.00	0.36 to 2.19
Quinolone vs macrolide	0	0	1.32	0.90 to 1.89	1.88	0.41 to 5.67	1.56	0.55 to 3.62
Macrolide + tetracycline vs macrolide	1	198	1.28	0.68 to 2.19	1.67	0.42 to 4.31	1.41	0.52 to 3.15
Macrolide + tetracycline vs quinolone	0	0	1.00	0.49 to 1.82	1.72	0.17 to 4.67	1.13	0.26 to 3.11

Abbreviations

CrI: credible interval; OR: odds ratio.