Treatment comparison		Hazard ratios: fixed effects (no class model)		Hazard ratios: fixed effects (exchangeable class model)		No. of trials (no. of participants)
Intervention	Comparator	Median	95% CrI	Median	95% CrI
AZM 250 mg once daily	Placebo	0.72	0.62 to 0.84	0.71	0.61 to 1.82	2 (1147)
AZM 250 mg once daily (three times per week )	AZM 250 mg once daily	0.80	0.44 to 1.45	0.84	0.50 to 1.36	0 (0)
AZM 250 mg once daily (three times per week)	Placebo	0.58	0.32 to 1.03	0.60	0.36 to 0.96	2 (133)
AZM 500 mg once daily (three times per week)	AZM 250 mg once daily (3x weekly)	0.93	0.48 to 1.78	0.91	0.51 to 1.57	0 (0)
AZM 500 mg once daily (three times per week)	AZM 250 mg once daily	0.74	0.52 to 1.04	0.75	0.54 to 1.04	0 (0)
AZM 500 mg once daily (three times per week)	Placebo	0.53	0.39 to 0.73	0.54	0.40 to 0.72	2 (108)
ERY 250 mg twice daily	AZM 500 mg once daily (three times per week)	1.19	0.79 to 1.81	1.16	0.79 to 1.74	0 (0)
ERY 250 mg twice daily	AZM 250 mg once daily (three times per week)	1.12	0.58 to 2.10	1.05	0.62 to 1.83	0 (0)
ERY 250 mg twice daily	AZM 250 mg once daily	0.88	0.64 to 1.21	0.88	0.65 to 1.18	0 (0)
ERY 250 mg twice daily	Placebo	0.64	0.48 to 0.85	0.63	0.48 to 0.82	10 (109)
ERY 125 mg three times daily	ERY 250 mg twice daily	0.86	0.46 to 1.62	0.88	0.50 to 1.50	0 (0)
ERY 125 mg three times daily	AZM 500 mg once daily (three times per week)	1.03	0.54 to 1.98	1.02	0.58 to 1.80	0 (0)
ERY 125 mg three times daily	AZM 250 mg once daily (three times per week)	0.96	0.42 to 2.14	0.93	0.47 to 1.80	0 (0)
ERY 125 mg three times daily	AZM 250 mg once daily	0.76	0.42 to 1.37	0.78	0.46 to 1.27	0 (0)
ERY 125 mg three times daily	Placebo	0.55	0.31 to 0.97	0.55	0.33 to 0.89	1 (36)
ERY 200 to 400 mg once daily	ERY 125mg three times daily	0.24	0.08 to 0.67	0.47	0.15 to 1.06	0 (0)
ERY 200 to 400 mg once daily	ERY 250 mg twice daily	0.21	0.07 to 0.51	0.41	0.14 to 0.97	0 (0)
ERY 200 to 400 mg once daily	AZM 500 mg once daily (three times per week)	0.25	0.09 to 0.62	0.48	0.17 to 1.04	0 (0)
ERY 200 to 400 mg once daily	AZM 250 mg once daily (three times per week)	0.23	0.07 to 0.64	0.44	0.14 to 1.02	0 (0)
ERY 200 to 400 mg once daily	AZM 250 mg once daily	0.18	0.07 to 0.43	0.36	0.13 to 0.89	0 (0)
ERY 200 to 400 mg once daily	Placebo	0.13	0.05 to 0.31	0.25	0.09 to 0.60	1 (109)
DOX 100 mg once daily	ERY 200‐400 mg once daily	8.35	2.77 to 27.91	4.93	1.66 to 15.88	0 (0)
DOX 100 mg once daily	ERY 125 mg three times daily	2.02	0.81 to 4.97	2.28	1.00 to 5.02	0 (0)
DOX 100 mg once daily	ERY 250 mg twice daily	1.74	0.80 to 3.74	2.01	0.97 to 3.93	0 (0)
DOX 100 mg once daily	AZM 500 mg once daily (three times per week)	2.09	0.94 to 4.53	2.34	1.12 to 4.67	0 (0)
DOX 100 mg once daily	AZM 250 mg once daily (three times per week)	1.93	0.89 to 4.08	2.11	1.00 to 4.31	1 (50)
DOX 100 mg once daily	AZM 250 mg once daily	1.54	0.73 to 3.19	1.76	0.88 to 3.33	0 (0)
DOX 100 mg once daily	Placebo	1.12	0.54 to 2.25	1.26	0.63 to 2.33	1 (49)
MOX 400 mg once daily (5 days every 4 weeks)	DOX 100 mg once daily	0.55	0.23 to 1.23	0.70	0.37 to 1.40	1 (50)
MOX 400 mg once daily (5 days every 4 weeks)	ERY 200‐400 mg once daily	4.59	1.37 to 15.69	3.47	1.47 to 9.44	0 (0)
MOX 400 mg once daily (5 days every 4 weeks)	ERY 125 mg three times daily	1.10	0.41 to 2.89	1.60	0.96 to 2.71	0 (0)
MOX 400 mg once daily (5 days every 4 weeks)	ERY 250 mg twice daily	0.96	0.40 to 2.17	1.41	1.03 to 1.92	0 (0)
MOX 400 mg once daily (5 days every 4 weeks)	AZM 500 mg once daily (3x weekly)	1.14	0.47 to 2.62	1.64	1.18 to 2.31	0 (0)
MOX 400 mg once daily (5 days every 4 weeks)	AZM 250 mg once daily (3x weekly)	1.06	0.45 to 2.40	1.48	0.91 to 2.47	1 (50)
MOX 400 mg once daily (5 days every 4 weeks)	AZM 250 mg once daily	0.85	0.37 to 1.86	1.24	1.00 to 1.55	0 (0)
MOX 400 mg once daily (5 days every 4 weeks)	Placebo	0.61	0.27 to 1.32	0.88	0.75 to 1.04	1 (49)
MOX 400 mg once daily (5 days every 8 weeks)	MOX 400 mg once daily (5 days every 4 weeks)	1.47	0.67 to 3.40	1.00	1.00 to 1.00	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	DOX 100 mg once daily	0.81	0.39 to 1.69	0.70	0.37 to 1.40	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	ERY 200‐400 mg once daily	6.68	2.83 to 18.35	3.47	1.47 to 9.44	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	ERY 125 mg three times daily	1.63	0.90 to 2.95	1.60	0.96 to 2.71	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	ERY 250 mg twice daily	1.41	1.01 to 1.96	1.41	1.03 to 1.92	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	AZM 500 mg once daily (three times per week)	1.68	1.18 to 2.39	1.64	1.18 to 2.31	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	AZM 250 mg once daily (three times per week)	1.55	0.85 to 2.82	1.48	0.91 to 2.47	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	AZM 250mg once daily2 (133)	1.25	1.00 to 1.56	1.24	1.00 to 1.55	0 (0)
MOX 400 mg once daily (5 days every 8 weeks)	Placebo	0.90	0.76 to 1.06	0.88	0.75 to 1.04	1 (1149)