Author	Class/antibiotic	Dose	COPD severity	Duration of treatment	Risk of bias
Brill 2015 (N = 99); UK (1 outpatient hospital department)	Quinolone/Moxifloxacin Tetracycline/Doxycycline Macrolide/Azithromycin	400 mg daily for 5 days every 4 weeks (pulsed) 100 mg daily (continuous) 250 mg three times per week (intermittent)	Moderate to severe FEV₁ 1.4 L	13 weeks	Unclear performance bias; detection bias judged as high