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. 2021 Mar 4;2021(3):CD008726. doi: 10.1002/14651858.CD008726.pub3

De‐Lalla 1988.

Study characteristics
Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women undergoing CS.

  • N = 300.


Exclusion criteria
  • Not documented.

Interventions Intervention: 2nd generation cephalosporin (C2).
  • Cefotetan.

  • 2 g; IV; single dose when the cord is clamped.

  • N = 106.


Comparator: broad spectrum penicillin (P2).
  • Mezlocillin.

  • 2 g; IV; single dose when the cord is clamped.

  • N = 194.


Subgroups
  • Type of CS: unclear


Comparisons: no usable data reported
Outcomes Fever > 38 ºC; endometritis; wound infection; UTIs; asymptomatic bacteriuria.
Notes Dates of study: not reported.
Setting: Obstetric and Gynecologic department of UCSC, Como, Italy.
Funding sources: not reported.
Declarations of interest: not reported.
Additional information
  • No data for this review

  • Conference abstract only.

  • Costs: this trial did not provide any information or comment on costs of treatment.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No information provided.
Allocation concealment (selection bias) Unclear risk No information provided.
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk No information provided.
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk No information provided.
Incomplete outcome data (attrition bias)
All outcomes Unclear risk No information provided.
Selective reporting (reporting bias) High risk We did not assess the trial protocol, but the conference abstract did not report pre‐specified outcomes to be assessed in the methods section.
Other bias Unclear risk No information provided. Also no information about funding source of study.