TABLE 1.
Biomarker KIM-1 summary for vancomycin-treated animals by dose fractionationa
| Vancomycin dosage (mg/kg/day) | Median KIM-1 concn (ng/ml) (IQR) [n] for dosing frequency |
|||
|---|---|---|---|---|
| QD | BID | TID | QID | |
| 300 | 10.70*,** (9.8–12.3) [5] | 9.5 (7.7–10.3) [5] | 2.3* (1.43–4.9) [6] | 1.46** (1.2–2.5) [6] |
| 400 | 10.5 (6.6–14.4) [5] | 13.3*** (13–16.5) [6] | 4*** (2.9–4.6) [9] | 6.4 (4.8–8.3) [6] |
a
Abbreviations: KIM-1, kidney injury molecule-1; IQR, interquartile range; QD, once daily; BID, twice daily; TID, three times daily; QID, four times daily. *, P = 0.03; **, P <0.01; ***, P < 0.001.