TABLE 2.

Inoculum change in non-CRAB compared to growth control

Antimicrobial regimen	Change in bacterial density (log10 CFU/ml) over 24, 48, and 72 h
	24 h	48 h	72 h
Monotherapy
Minocycline 200 mg load, 100 mg Q12h (SD)	–0.59	+0.64	+0.23
Minocycline 700 mg load, 350 mg Q12h (HD)	−2.01	−1.11	+0.17
Meropenem 1 g Q8h	−2.24	−0.79	−0.30
Polymyxin 2.5 mg/kg Q12h	−2.7d	−0.26	−0.21
Sulbactam 1 g Q6h	-0.59	−0.5	−0.39
Dual Therapy
Minocycline SD + meropenem 1 g Q8h	−2.69d	−0.28	−0.15
Minocycline SD + sulbactam 1 g Q6h	−0.58	−0.17	−0.64
Minocycline SD + polymyxin B 2.5 mg/kg Q12ha	−3.39d	−2.87d	−3.2d
Meropenem 1g Q8h + sulbactam 1 g Q6h	−2.59d	−0.66	+0.07
Minocycline HD + meropenem 6 g/24 h CIc	−4.63d	−4.52d	−3.96d
Minocycline HD + sulbactam 9 g/24 h CI	−2.82d	−1.51	−1.51
Triple Therapy
Minocycline HD + meropenem 6 g/24 h CI + sulbactam 9g/24h CIb	−3.97d	−3.92d	−4.32d

^aEnhanced activity compared to minocycline SD alone at 24 h, 48 h.

^bEnhanced activity compared to minocycline HD alone at 48 h, 72 h.

^cEnhanced activity compared to minocycline HD alone at 24 h, 48 h, and 72 h; enhanced activity compared to polymyxin B alone at 72 h. CI, continuous infusion; HD, high dose; SD, standard dose.

^dP ≤ 0.05.