TABLE 3.

Inoculum change in CRAB compared to growth control

Antimicrobial regimenc	Change in bacterial density (log10 CFU/ml) over 24, 48, and 72 h
	24 h	48 h	72 h
Monotherapy
Minocycline 200 mg load, 100 mg Q12h (SD)	+0.17	+0.24	−0.01
Meropenem 1 g Q8h	−0.30	−0.69	−0.40
Meropenem 2 g Q8h	−0.36	−0.49	−0.21
Polymyxin B 2.5 mg/kg Q12h	−2.32d	−1.05	−1.34d
Sulbactam 1 g Q6h	−1.15	−1.25	−0.62
Dual Therapy
Minocycline SD + meropenem 2 g Q8h	−0.34	−0.47	−0.22
Minocycline SD + sulbactam 1 g Q6h	−0.69	−0.44	−0.46
Minocycline SD + polymyxin B 2.5 mg/kg Q12ha	−3.40d	−0.88	+0.24
Meropenem 2 g Q8hb + sulbactam 1 g Q6h	−0.93	−0.62	−0.29
Minocycline HD + polymyxin B	−1.63	−0.76	−0.19
Polymyxin B + sulbactam 9 g/24 h CI	−1.38	−1.81d	−0.50
Triple Therapy
Minocycline 700 mg load, 350 mg Q12h (HD) + meropenem 6 g/24 h CI + sulbactam 9 g/24 h CI	−2.51d	−1.68	−1.45d
Minocycline HD + polymyxin B + sulbactam 9 g/24 h CI	−2.60d	−2.18d	−2.13d

^aEnhanced activity compared to minocycline SD alone at 24 h

^bMeropenem exposure maximized for CRAB isolates due to resistance

^cCI, continuous infusion; HD, high dose; SD, standard dose.

^dP ≤ 0.05.