TABLE 6.

Values of achieved and targeted pharmacokinetic parameters

Regimena	fCmax (μg/ml)		Half-life (h)		Ke		% Protein binding	fAUC (μg · h/ml)		fAUC/MIC CRAB (non-CRAB)		% T>MIC (CRAB [non-CRAB])
	Targeted	Achieved	Targeted	Achieved	Targeted	Achieved	Targeted	Targeted	Achieved	Targeted	Achieved	Targeted	Achieved
Minocycline 200 mg load plus 100 mg Q12h	0.84 (0.6–1.59)	0.78b	11	10.56	0.06	0.07	76	14.4	14.1	7.2 (28.7)	7.0 (28.1)	—	—
Minocycline 700 mg load, 350 mg Q12h (HD)	2.94	2.73b	11	10.56	0.06	0.07	76	43.4	42.4	21.7 (86.7)	21.2 (84.8)	—	—
Polymyxin B 2.5 mg/kg/day	1.75	1.77b	4.3	7.44	0.16	0.1	79	21.8	31.3	10.9 (43.7)	15.6 (62.5)	—	—
Meropenem 1g Q8h	48.02	38.36c	1	1	0.69	0.69	2	335.8	287.5	—	—	0 (≥50)	0d (100)
Sulbactame 1g Q6h	26.66	35.14c	1	1	0.69	0.69	38	253.7	338.8	—	—	≥60 (≥60)	67 (83)

^aPharmacokinetic parameters extrapolated to other regimen based on achieved K_e.

^bDetermined with in house bioassay.

^cDetermined by HPLC analysis.

^dUnable to achieve T_>MIC as this isolate was meropenem resistant.

^eTested as ampicillin-sulbactam.