TABLE 3.

Worm burdens and egg burdens after RAD treatment in mice infected with S. japonicum^a

Exptl grouping and drug dose	Route of administration	No. of mice	Mean worm load ± SD (reduction rate [%])	Mean egg load (LEPG) ± SD (% decrease)
Batch A: treatment at days 1–4 postinfection for killing schistosomula
RAD at 50 mg/kg · day	Intraperitoneal injection (once a day for 4 days)	6	12.80 ± 5.64 (37.25)†	1,100 ± 496 (20.28)
RAD at 100 mg/kg · day		6	9.60 ± 3.61 (52.29)†	600 ± 179 (56.52)†
RAD at 200 mg/kg · day		6	11.80 ± 2.93 (42.16)†	460 ± 273 (66.67)†
RAD at 400 mg/kg · day		6	1.80 ± 1.79 (91.18)‡Δ	192 ± 103 (86.01)‡Δ
DMSO + RPMI 1640		7	20.40 ± 3.93	1,380 ± 299
RPMI 1640		6	26.20 ± 5.18	1,812 ± 343
Batch B: treatment at day 30 postinfection for killing adult worms
RAD at 100 mg/kg · day	Intraperitoneal injection (once a day for 4 days)	5	13.80 ± 4.70 (10.97)	5,580 ± 3,949 (36.71)
RAD at 200 mg/kg · day		5	7.83 ± 2.79 (49.48)†	3,800 ± 1,364 (56.70)†
RAD at 400 mg/kg · day		6	6.91 ± 3.15 (55.42)†§	3,272 ± 2,142 (62.87)†
DMSO + RPMI 1640	Single oral injection	7	15.50 ± 3.35	8,816 ± 2,149
PZQ at 300 mg/kg · day		6	6.60 ± 2.73 (57.42)†	2,583 ± 1,282 (70.70)‡
Batch C: treatment at day 30 postinfection for killing adult worms	Oral injection
RAD at 200 mg/kg · day	Once a day for 2 days	5	21.21 ± 4.05 (33.75)†§
PZQ at 300 mg/kg · day	Single day	6	12.70 ± 4.20 (60.31)†
PZQ at 300 mg/kg · day	Once a day for 2 days	6	0.80 ± 0.75 (97.50)‡Δ
Tween 80		7	32.00 ± 3.19

^a†, P > 0.05; ‡, P > 0.01 (compared to the solvent control group). Δ, P > 0.05 (compared to mice exposed to low-dose drugs). §, P < 0.05 (two routes of administration were compared).