FIG 1.

Prediction-corrected visual predictive check for final model by study and renal function group. Results for 500 simulations. Renal function groups defined by CrCL were as follows: augmented, ≥120 ml/min; normal or mild, 60 to <120 ml/min; moderate, severe, or end-stage renal disease (ESRD), 5 to <60 ml/min. Semilog scale. Solid line, observed median; dashed line, observed 2.5th and 97.5th percentiles; dark-gray shaded area, model-predicted 95% confidence interval of median; gray shaded area, model predicted 95% confidence intervals of 2.5th and 97.5th percentiles.