TABLE 2.
Therapy and therapy outcomea
| Parameter | Result for recipients of: |
|
|---|---|---|
| Prophylaxis | Treatment | |
| Dose and exposure, median (IQR) | ||
| Loading dose, mg/kg/day | 4.7 (2.8–5.3) | 5.6 (3.8–8.8) |
| AUC0–24 h on day 1, mg · h/liter | 137.0 (11.5–169.7) | 174.0 (108.9–345.6) |
| Cmin on day 1, mg/liter | 4.5 (3.4–6.0) | 6.4 (3.9–12.7) |
| Dose on day 5, mg/kg/day | 1.4 (1.1–4.0) | 3.8 (2.7–6.7) |
| AUC0–24 h on day 5, mg · h/liter | 183.9 (70.3–469.4) | 405.0 (239.2–587.9) |
| Cmin on day 5, mg/liter | 6.5 (2.0–15.5) | 13.3 (7.7–20.7) |
| Therapy discontinuation, no. (%) | ||
| Successful therapy | 21 (75.0) | 15 (71.4) |
| Breakthrough infection | 3 (10.7) | NA |
| Adverse event | 0 (0.0) | 0 (0.0) |
| Lack of effectiveness | 3 (10.7) | 0 (0.0) |
| Death | 1 (3.6) | 6 (28.6) |
a
Abbreviations: AUC, area under the curve; Cmin, trough concentration; NA, not applicable.