TABLE 2.
Number of mutated loci reported by Seifert et al. (9) and this study in INHr isolates
| Location of mutation(s) | No. of mutated loci reported |
|||
|---|---|---|---|---|
| Seifert et al. | This study | Common to both studiesc | Cumulative in both studies | |
| katG promoter | 4 | 0 | 0 (0) | 4 |
| katG ORF | 198 | 75 | 42 (18) | 231 |
| inhA promotera | 22 | 11 | 5 (22) | 28 |
| inhA ORF | 22 | 6 | 1 (5) | 27 |
| oxyR′-ahpC intergenic region | 22b | 16 | 11 (41) | 27 |
| ahpC ORF | 9 | 2 | 0 (0) | 11 |
a
inhA promoter mutations include mutations in fabG1 open reading frame (ORF) because they create alternative promoters for inhA and mutations upstream of fabG1 because they act as promoters of the entire operon, which includes inhA.
b
Seifert et al. reported a mutation in codon 13 of oxyR′. Because oxyR′ is an inactive pseudogene in M. tuberculosis (75), this position is not included in this analysis.
c
Numbers in parentheses are the percentages of mutated loci common to both studies.