TABLE 4.
Regional prevalence of canonical mutations (katG315, inhA-15, and inhA-8)
Region | Prevalence of mutations (%) in locusc: |
Wild typeb | |||
---|---|---|---|---|---|
katG315 | inhA-15 | inhA-8 | oxyR′-ahpCa | ||
Asia | 67.70% | 12.85% | 1.12% | 2.71% | 18.41% |
Africa | 88.39% | 7.10% | 4.26% | 0.52% | 4.90% |
Americas | 71.72% | 18.66% | 2.04% | – | 11.08% |
Europe | 75.00% | 37.50% | – | – | – |
Global | 73.59% | 13.56% | 1.83% | 1.84% | 14.42 |
The “oxyR′-ahpC” column reflects the prevalence of any mutation in this region.
The “Wild type” column displays the frequency of isoniazid-resistant isolates that harbored no mutations in the three considered regions. Isolates that only harbored synonymous mutations in coding regions have also been included in the “Wild type” column.
Because some isolates harbor multiple canonical mutations, percentages in each row add up to more than 100%. This table only includes 48 of the 52 included studies. The remaining four studies did not provide the regional information per isolate and are excluded from this table (–).