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. 2021 Feb 17;65(3):e02091-20. doi: 10.1128/AAC.02091-20

TABLE 4.

Regional prevalence of canonical mutations (katG315, inhA-15, and inhA-8)

Region Prevalence of mutations (%) in locusc:
Wild typeb
katG315 inhA-15 inhA-8 oxyR′-ahpCa
Asia 67.70% 12.85% 1.12% 2.71% 18.41%
Africa 88.39% 7.10% 4.26% 0.52% 4.90%
Americas 71.72% 18.66% 2.04% 11.08%
Europe 75.00% 37.50%
Global 73.59% 13.56% 1.83% 1.84% 14.42
a

The “oxyR′-ahpC” column reflects the prevalence of any mutation in this region.

b

The “Wild type” column displays the frequency of isoniazid-resistant isolates that harbored no mutations in the three considered regions. Isolates that only harbored synonymous mutations in coding regions have also been included in the “Wild type” column.

c

Because some isolates harbor multiple canonical mutations, percentages in each row add up to more than 100%. This table only includes 48 of the 52 included studies. The remaining four studies did not provide the regional information per isolate and are excluded from this table (–).