TABLE 2.
MICs of omadacycline and comparator antimicrobials against 25 slowly growing mycobacteria other than Mycobacterium avium complexa
| Mycobacterium species (n)b | MIC type | MIC (μg/ml) of: |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OMC | DOX | MIN | AMK | SXT | LZD | CIP | MXF | CLR | RFB | RIF | ||
| M. arupense (6) | Range | 1–>16 | 0.5–16 | 0.5–8 | ≤2–64 | ≤0.5/9.5–4/76 | ≤1–32 | >4 | 8–>16 | ≤0.06–4 | ≤0.25–0.5 | 0.5–>2 |
| 50% | >16 | 8 | 8 | 16 | 2/38 | 16 | >4 | >16 | 1 | ≤0.25 | 2 | |
| 90% | >16 | 16 | 8 | 64 | 4/76 | 32 | >4 | >16 | 4 | 0.5 | 2 | |
| M. simiae (7) | Range | >16 | ≥16 | ≥8 | 8–64 | 2/38–4/76 | 16–>32 | 2–>4 | 2–>8 | 2–4 | >2 | >2 |
| 50% | >16 | >16 | ≥8 | 16 | 4/76 | ≥32 | >4 | 4 | 4 | >2 | >2 | |
| 90% | >16 | >16 | ≥8 | 64 | 4/76 | ≥32 | >4 | >8 | 4 | >2 | >2 | |
| M. kansasii (5) | Range | 4–>16 | 0.12–16 | ≤0.25–>8 | ≤2–8 | ≤0.5/9.5–2/38 | ≤1–32 | ≤0.12–4 | ≤0.06–2 | 0.12–1 | ≤0.25 | ≤0.25–>2 |
| 50% | 8 | 4 | 2 | 8 | ≤0.5/9.5 | 2 | 1 | 0.12 | 0.25 | ≤0.25 | 2 | |
| 90% | 16 | 16 | >8 | 8 | 2/38 | 32 | 4 | 2 | 1 | ≤0.25 | >2 | |
| M. marinum (2) | Range | 4–16 | 1–2 | 0.5–1 | ≤2 | ≤0.5/9.5 | ≤1–2 | 4 | 0.5 | 0.25–0.5 | ≤0.25 | 1 |
| M. lentiflavum (3) | Range | 4–>16 | 4–16 | 4–16 | 4 | ≤0.5/9.5–1/19 | 8–16 | 0.5–2 | 0.5–1 | 0.12–0.5 | ≤0.25 | >2 |
| 50% | >16 | 8 | 8 | 4 | 1/19 | 8 | 2 | 1 | 0.25 | >2 | ≤0.25 | |
| M. paraffinicum (2) | Range | 8–>16 | 4–8 | 4 | ≤2–4 | 1/19 | 16–32 | 0.25–>4 | 0.25–1 | 0.25–1 | ≤0.25 | 2 |
a
OMC, omadacycline; DOX, doxycycline; MIN, minocycline; AMK, amikacin; SXT, trimethoprim sulfamethoxazole; LZD, linezolid; CIP, ciprofloxacin; MXF, moxifloxacin; CLR, clarithromycin; RFB, rifabutin; RIF, rifampin.
b
The MIC50 and/or MIC90 was not calculated for species with <5 isolates tested.