TABLE 1.

In vitro antifungal susceptibility of 284 Trichosporon asahii clinical isolates tested against triazoles and amphotericin B

Anatomic site or genotypea	No. of isolates	MIC (μg/ml)
		Fluconazole				Voriconazole				Posaconazole				Amphotericin B
		Range	50%	90%	GM	Range	50%	90%	GM	Range	50%	90%	GM	Range	50%	90%	GM
Anatomic sites
Urine	157	0.25 to ≥64	2	4	2.47	0.03–2	0.06	0.125	0.07	0.03–2	0.25	0.5	0.21	0.25 to ≥16	2	4	1.65
Blood/CVC	71	0.25 to 32	2	8	2.08	0.03–1	0.06	0.125	0.07	0.03–1	0.25	0.5	0.18	0.25 to ≥16	1	4	1.42
Respiratory	16	0.5 to 8	1	4	1.54	0.03–0.125	0.06	0.06	0.06	0.06–0.25	0.125	0.25	0.16	1 to 8	1	2	1.35
Integumentary	11	1 to 6	2	4	2.13	0.03–0.25	0.06	0.06	0.06	0.03–1	0.125	0.25	0.17	1 to 4	1	2	1.29
S.S.N.B.	11	1 to 16	2	4	2.57	0.03–1	0.125	0.125	0.12	0.06–1	0.25	0.25	0.21	0.5 to 4	1	4	1.55
Others	18	1 to 8	2	4	2.16	0.03–0.5	0.06	0.125	0.06	0.03–0.5	0.125	0.25	0.14	0.25 to ≥16	1	4	1.71
Genotypes
G1	216	0.25 to ≥64	2	8	2.30	0.03–2	0.06	0.25	0.06	0.03–2	0.25	0.5	0.18	0.25 to ≥16	2	4	1.57
G3	28	0.5 to 16	2	2	1.95	0.03–1	0.06	0.125	0.08	0.06–1	0.25	0.25	0.22	0.5 to ≥16	1	1	1.19
G4	8	1 to 4	1	2	1.54	0.03–0.125	0.06	0.06	0.05	0.125–0.25	0.125	0.125	0.13	0.5 to 2	1	2	1.09
G5	21	0.5 to 4	2	2	1.61	0.03–0.125	0.06	0.125	0.04	0.03–0.5	0.25	0.5	0.16	0.25 to 4	2	4	1.14
G7	11	1 to 32	2	16	4.83	0.06–1	0.125	0.5	0.19	0.06–1	0.5	1	0.36	1 to 4	2	4	2.13

^aCVC, catheter tips; SSNB, sterile sites, nonblood.